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We discuss the implications of EPHB6's effect on catecholamine exocytosis and secretion for blood pressure regulation. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of a ninth of diabetic patients. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvasculature. Revealed through retinal vascular digests, a subsequent increase in basement membrane