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ficities of bnAbs will be required to be sufficiently broad to prevent the escape of HIV-1 strains during transmission. A fully protective HIV-1 vaccine needs to induce durable high titers of bnAbs that can be generated by a sequential set of Env immunogens for expansion and maturation of bnAb B cell lineages in a permitted immunological environment. Moreover, multiple specificities of bnAbs will be required to be sufficiently broad to prevent the escape of HIV-1 strains during transmission.Progesterone is an important natural hormone r