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The reduced glutathione levels were lower (p less then 0.05) in 5-FU group than in the control group although its level was higher (p less then 0.05) in TA and CHX groups than in the 5-FU group. Glutathione peroxidase activity was also higher (p less then 0.05) in TA group than the 5- FU group. In histopathological analyses, treatment with TA reduced 5-FU induced inflammatory cell infiltration and ulceration (p less then 0.001) but not with CHX.In conclusion, we observed that TA and CHX treatment modulated chemotherapy induced oxidative i
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