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In particular, we discuss the usage of CTC for screening and stratifying patients' risk. Moreover, we will discuss the potential role of CTCs for treatment specification and treatment monitoring.Enteropathy may be the first presentation of immunodeficiency or it may occur during the course of the disease and in association with malabsorption in patients affected by primary antibody diseases. For these patients, immunoglobulin G (IgG) replacement therapy prevents infectious and non-infectious complications. Nonetheless some patients cannot