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The translational potential for this article an improved comprehension of the role of extracellular vesicles in regenerative medicine will contribute to a novel and encouraging therapy for OA patients. © 2019 The Author(s).Background/objective Orthopaedic implants are important devices aimed at relieving pain and enhancing flexibility. Staphylococcal illness and aseptic loosening are a couple of common occasions associated with inflammatory osteolysis that cause implant failures. Bon