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Human immunodeficiency virus and Covid-19 (or SARS-CoV-2) differ in their incubation distributions and in their susceptibility to immunologic defense. These features affect our ability to predict the course of these epidemics and to control them.In this commentary, we highlight the importance of (1) carefully considering and clarifying whether a marginal or conditional treatment effect is of interest in a population-adjusted indirect treatment comparison; and (2) developing distinct methodologies for estimating the different measures of