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ferences between groups ( 0.05). Overexpression of HIF-1α can promote SHED to differentiate into vascular endothelial cells by activating Wnt/β-catenin signaling pathway. Overexpression of HIF-1α can promote SHED to differentiate into vascular endothelial cells by activating Wnt/β-catenin signaling pathway. To investigate clinical application of the free peroneal artery perforator flap in soft tissue defect of foot and ankle. The clinical data of 18 patients with soft tissue defects of foot and ankle who were repaired with free peron