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Askin's tumor is a kind of aggressive tumor and extremely rare. To date, the treatment is uncodified and the prognosis for patients with this tumor remains bleak. Herein we report a case of a giant Askin's tumor in the chest wall that following diagnosis was successfully treated with surgical resection.Topical immunotherapy with diphenylcyclopropenone (DPCP) is considered to be the most effective treatment of severe AA. However, the mechanism is unclear and an early predictor for the efficacy needs to be explored. The TSLP/OX40L/IL-13 pathw