https://www.selleckchem.com/pr....oducts/eeyarestatin-
ther research to better understand host-bacteria interactions and provides potential prophylactic strategies for infections.A novel selection was developed for mutants of the C-terminal domain of RpoA (α-CTD) altered in activation by the TyrR regulatory protein of Escherichia coli K-12. This allowed the identification of an aspartate to asparagine substitution at residue 250 (DN25 as an activation-defective (Act-) mutation. Amino acid residues known to be close to D250 were altered by in vitro mutagenesis, and the substitutions