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Techniques A rat type of remifentanil-induced postoperative hyperalgesia (RIH) was set up, which offered diminished paw detachment mechanical threshold (PWMT) and paw withdrawal thermal latencyment of RIH by managing TRPA1 in DRG neurons. Blocking TLR4 and TRPA1 might serve as a promising therapeutic strategy for RIH.Important neurotrophic elements being possibly tangled up in degenerative intervertebral disc (IVD) disease associated with the spine's lumbosacral (L/S) area include glial cell-derived neurotr
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