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OBJECTIVES Compare bypass surgery and endovascular revascularization of the femoropopliteal segment in patients with peripheral arterial disease (PAD) and critical limb-threatening ischemia (CLTI). METHODS Single center study including patients undergoing first-time lower extremity intervention with peripheral bypass surgery or percutaneous transluminal angioplasty with or without stenting (PTA/S) of the femoropopliteal segment due to CLTI from 2011 to 2015. Based on prospective entered data from the Danish Vascular Registry and primar