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Right here we aimed to explore the potential role of IL-27 and CD4+IL-10+ T cells when you look at the pathogenesis of SS. The IL-27 gene knockout non-obese diabetic (Il-27-/-NOD) mice had been produced and inserted with exogenous IL-27. Exogenous injection of IL-27 and neutralization of IL-27 with anti-IL-27 antibody in NOD mice were performed. The histopathologic changes in submandibular glands, lacrimal glands and lung, salivary flow price, and percentages of CD4+IL-10+ T cells were determined. And, ov