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In addition, FA-PtCPs NRs could be used as fluorescent probes for in-situ bioimaging. Therefore, this photothermal sensing platform has a broad prospect in the field of point-of-care detection of cancer cells.Early diagnosis and monitoring of SARS-CoV-2 virus is essential to control COVID-19 outbreak. In this study, we propose a promising surface enhanced Raman scattering (SERS)-based COVID-19 biosensor for ultrasensitive detection of SARS-CoV-2 virus in untreated saliva. The SERS-immune substrate was fabricated by a novel oil/water/oil (