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In this manuscript, a data-defined naïve Bayes (DN-based decision scheme for nonlinear mitigation is presented for an orbital angular momentum (OAM) mode-division multiplexed optical fiber communication system. Due to the inherent nonlinearity characteristic of opto-electronic devices, the strong nonlinear impairments are deemed inevitable in OAM mode-division multiplexed transmission, leading to severely nonlinear effects. A DNB algorithm based on the prior probability distribution is adopted to mitigate the strong device nonlinearit