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Here, by single-nucleus RNA sequencing, we map the dynamic transcriptional landscape of five distinct cardiomyocyte populations in healthy, injured, and regenerating mouse minds. We identify immature cardiomyocytes that go into the cellular pattern after injury and vanish due to the fact heart loses the capacity to replenish. These proliferative neonatal cardiomyocytes display a unique transcriptional program determined by nuclear transcription aspect Y subunit alpha (NFYa) and a