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These observations demonstrate that splicing regulators modulate splice site selection allosterically.The majority of mouse and human genes are subject to alternative cleavage and polyadenylation (APA), which most often leads to the expression of two or more alternative length 3' untranslated region (3' UTR) mRNA isoforms. In neural tissues, there is enhanced expression of APA isoforms with longer 3' UTRs on a global scale, but the physiological relevance of these alternative 3' UTR isoforms is poorly understood. Calmodulin 1 (Calm1) is
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