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065, null to small effect size). Both drugs predicted increased PTSD symptoms when combined with severe pain during labour. This study was observational, thus drug administration was not randomised. Additionally, PTSD symptoms were self-reported. Peritraumatic N O administration may reduce subsequent PTSD symptom severity and thus be a potential avenue for PTSD secondary prevention. This might also be the case for morphine. However, the role of severe peritraumatic pain in context of drug administration deserves further investigation. Peritraumatic N2O admi