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greater than 200 mm Hg. A phase 3 multicenter randomized double-blinded clinical trial is under way to validate these findings. This pilot study showed that IV immunoglobulin significantly improved hypoxia and reduced hospital length of stay and progression to mechanical ventilation in coronavirus disease 2019 patients with A-a gradient greater than 200 mm Hg. A phase 3 multicenter randomized double-blinded clinical trial is under way to validate these findings. To propose the optimal timing to consider tracheostomy insertion for weanin