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In this prospective review, we summarize the importance of the glycocalyx and its potential as a therapeutic target in cases of systemic COVID-19.It is still as yet not known if the oscillation in heart rate (hour) caused by sleep-disordered breathing (SD in clients with heart failure entails considerable chronotropic effects. We hypothesised that since cyclical alterations in air flow and arterial blood fumes during SDB affect HR through multiple and complexly interactin