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Nanoparticles based drug delivery system offers an alternative strategy to overcome several therapeutic limitations of various human ailments, particularly in age-linked Alzheimer's disease. Results of our previous cell-free studies indicated that α-bisabolol loaded solid lipid nanoparticles (ABS) significantly inhibited the aggregation of Aβ25-35. The present study intended to evaluate the neuroprotective effect of ABS against Aβ25-35 induced toxicity in Neuro-2a cell lines. The results of in vitro cell line study revealed that pretreat