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Our outcomes demonstrated that AOH is a solid inhibitor of CYP1A2 (IC50 = 0.15 μM) and CYP2C9 (IC50 = 7.4 μM). In line with the AOH depletion assays when you look at the existence of CYP enzymes, CYP1A2 is primarily involved, while CYP2C19 is moderately active in the CYP-catalyzed biotransformation for the mycotoxin. AOH became a strong inhibitor of each OATP transporter examined (IC50 = 1.9 to 5.4 μM). In inclusion, both direct and indirect assays suggest the involvement of OATP
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