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59-1.0 and 1.00 (95% CI 0.83-1.0 for isoniazid resistance. For rifampicin resistance, corresponding values in subgroups with Ct values less then 29 were respectively 0.89 (95% CI 0.52-1.0, 0.98 (95% CI 0.91-1.0, 0.80 (95% CI 0.50-0.94) and 0.99 (95% CI 0.92-1.0.CONCLUSIONS DNA-based early LPA with remnant DNA from respiratory samples was feasible and accurate when the Ct values were low.BACKGROUND Screening for active TB using active case-finding (ACF) may reduce TB incidence, prevalence, and mortality; however, yield of ACF i