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Another haplotype at the locus may reflect a secondary selection signal, although its functional impact is unknown. © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.Sipuleucel-T is an autologous cellular immunotherapy that induces an immune response targeted against prostatic acid phosphatase (PAP) to treat asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). In the phase III IMPACT study, sipuleucel-T was associated with a sta