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4% and 66%; specificity 91.4% and 91.5%; and accuracy 83.7% and 81.4%; all P = NS). Conversely, more patients required liver biopsy after 2D-SWE-SSI (24.6% vs. 15.3%; P less then 0.001). Performing a second elastography technique in patients with unreliable or grey zone (between 8 and10 kPa) results greatly decreased the need for liver biopsy (42/577; 7.3%). The diagnostic performances (accuracy, sensitivity, and specificity) of FIB-4/2D-SWE-SSI/VCTE and FIB-4/VCTE/2D-SWE-SSI were comparable (81.1%, 71.5%, and 87.9% vs. 81.3%, 69.7%, an
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