https://cb-839inhibitor.com/lo....ok-at-serious-respon
, the N-methylpurine adducts), which represent up to 90percent of TMZ-generated DNA adducts, may also contribute to radiosensitization. Unfortuitously, at concentrations attainable in clinical rehearse, the alkylation capability of TMZ cannot overwhelm the fix of N-methylpurine adducts to effortlessly exploit these lesions. The present healing application of TMZ therefore faces two primary obstacles (i) the stochastic existence of MGMT and (ii) a blunted radiosensitization potential at physiologic concent
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