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How Does ADHD Medication Work? When a neuron transmits a message to another neuron, it makes use of neurotransmitters, chemicals. These need to travel through a tiny gap known as a synapse. Some ADHD medications make the transmission of these messages more efficient. They can either aid in the release of neurotransmitters more or slow the process of reuptake (called Reuptake inhibitors). Doctors put patients suffering from ADHD on a low dose of medication, and then monitor the