https://www.selleckchem.com/pr....oducts/derazantinib.
The controlled mono-addition of indolizines to isatins under very mild conditions is described. The reaction occurs in water using diphenylphosphate as the catalyst, which is dramatically accelerated by surfactant addition. 3-Hydroxy-3-indolizinyl-2-oxindole scaffolds were synthesized in up to 99% yield. Notably, in organic solvents only bis-addition products were observed.An in-depth understanding of the microscopic reaction mechanism on a nonmetal-doped catalytic system at the atomic level is one of the critical approaches to
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