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Overall, this study reveals a new inorganic nanosystem and proposes a new strategy for treating tumors in combination with immunotherapy. The present work illustrates the new opportunities for the treatment of primary tumors.The delivery of therapeutics to the brain in an efficient, noninvasive manner continues to be a major unmet need in the field of drug delivery. One significant impediment to brain delivery results from the existence of the physical yet dynamic blood-brain barrier (BB. Despite the many, often complex strategies that