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g. greater than 15 billion k-mers). Competing dynamic methods e.g., FDBG (Crawford et al., 2018) cannot be constructed on large scale datasets, or cannot support both addition and deletion e.g., BiFrost (Holley and Melsted, 2019). Availability DynamicBOSS is publicly available at https//github.com/baharpan/dynboss. Supplementary information Supplementary data are available at Bioinformatics online.Anastomotic stricture is a common complication of esophageal atresia (EA) repair. Such strictures are managed with dilation or other therape