https://www.selleckchem.com/pr....oducts/PD-0332991.ht
Failed total knee arthroplasties with large bone defects are increasing rapidly because of the growing population of young, active patients undergoing primary total knee arthroplasty. There are limited options when tibial metaphyseal bone loss is so extensive that a tibial component with augments and thickest available polyethylene cannot fill flexion and extension gaps once the femoral component is appropriately positioned. Previously, allograft or megaprostheses would be required. However, allografts require contouring and fixation
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