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This study aimed to describe sac ligation and sequential closure for the management of giant omphalocele (GO) and analyze its outcomes. The medical records of 13 neonates with GO treated at a tertiary general hospital between July 2012 and April 2020 were reviewed. Sac ligation and progressive external compression were performed on most cases immediately after birth. Staged closure with or without a prosthetic patch was conducted after a period of sac suspension. Sac ligation-traction-compression was performed on 12 cases, of which 10 u