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Thus, our findings reveal new associations between leprosy and the HLA-DPB1 locus and confirm previous associations between the HLA-C locus and leprosy.The greenhouse gas nitrous oxide (N2O) is produced in activated sludge tanks as a byproduct of nitrification and heterotrophic denitrification. Insufficient knowledge on how microbiological N2O generation and degradation pathways impact N2O emissions in activated sludge tanks still hampers the development of effective mitigation strategies. Our research contributes to overcome this gap by