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Because of retina abnormalities of diabetic patients, the most common vision-threatening disease is diabetic retinopathy (DR). The DR diagnosis and prevention are challenging tasks as they may lead to vision loss. According to the literature analysis, the shortcomings in existing studies, such as failed to reduce the feature dimension, higher execution time, and higher computational cost, unable to tune the hyper-parameters, such as a number of hidden layers and learning rate, more computational complexities, higher cost, and so forth,