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ICU professionals are at risk of developing burnout due to coronavirus disease 2019. This study assesses the prevalence and incidence of burnout symptoms and moral distress in ICU professionals before and during the coronavirus disease 2019 crisis. This is a longitudinal open cohort study. Five ICUs based in a single university medical center plus another adult ICU based on a separate teaching hospital in the Netherlands. All ICU professionals were sent a baseline survey in October-December 2019 (252 respondents, response rate 53%), and