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The primary outcome is the proportion of participants who achieve ≥ 4-fold RPR titer decrease at 3 or 6months post-treatment. Clinical trials evaluating the efficacy of alternative antibiotics to penicillin are urgently needed. Clinicaltrials.gov NCT03660488 . Registered on 4 September 2018. Clinicaltrials.gov NCT03660488 . Registered on 4 September 2018. Haem is a key metabolic factor in the life cycle of the malaria parasite. In the blood stage, the parasite acquires host haemoglobin to generate amino acids for protein synthesis and