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Our structural and biochemical data therefore provide an important framework for the mechanistic understanding of nucleoside transporters of the NHS family.Allosteric proteins with multiple subunits and ligand binding sites are central in regulating biological signals. cAMP receptor protein from Mycobacterium tuberculosis (CRPMT is a global regulator of transcription composed of two identical subunits, each one harboring structurally conserved cAMP and DNA binding sites. The mechanisms by which these four binding sites are allostericall
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