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Further, they did not contain known KP neuron markers of the human infundibular nucleus, neurokinin B, Substance P and cocaine- and amphetamine-regulated transcript but received afferent input from these KP neurons. CONCLUSIONS Identification and positive estrogenic regulation of KP neurons in the human rostral hypothalamus challenge the long-held view that positive estrogen feedback may be restricted to the mediobasal part of the hypothalamus in primates and point to the need of further anatomical, molecular and functional studies of ro