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clusters that contained a large gap in time (1year) between infections and may be indicative of intermediate transmissions via undiagnosed individuals. The large number of active and growing clusters among MSM are the driving force of the ongoing epidemic in NSW for subtype B and CRF01_AE. The large number of active and growing clusters among MSM are the driving force of the ongoing epidemic in NSW for subtype B and CRF01_AE.Disruptions to the maternally inherited allele UBE3A, encoding for an E3 ubiquitin ligase, leads to the manif