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We further demonstrate that a previously unknown function of TRIM22 protein predicted by QAUST can be experimentally validated. QAUST can be accessed at http//www.cbrc.kaust.edu.sa/qaust/submit/.Genome-scale metabolomics analysis is increasingly used for pathway and function discovery in the post-genomics era. The great potential offered by developed mass spectrometry (MS)-based technologies has been hindered, since only a small portion of detected metabolites were identifiable so far. To address the critical issue of low identificatio