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Periodontal disease has been linked to the development of Alzheimer's disease in people. It is theorized that the chronic inflammatory condition characteristic of oral dysbiosis in patients with periodontal disease leads to disruption of the blood-brain barrier, cytotoxin- and pathogen-induced brain damage, and accumulation of neurotoxic β-amyloid. In this inflammatory theory of Alzheimer's disease, β-amyloid-a known antimicrobial protein-accumulates in response to oral pathogens. Canine cognitive dysfunction (CCD) is considered a natur