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Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has profound quality of life and economic consequences for individuals, their family, formal services and wider society. Little is known about which therapeutic interventions are more cost-effective. A systematic review was carried out to identify and critically appraise the evidence on the cost-effectiveness of CFS/ME interventions. The review protocol was prespecified (PROSPERO CRD42018118731). Searches were carried out across two databases-MEDLINE (1946-202 and EMBASE (1974-202. Additional s