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ANN based fitting indicates better performance level to predict the degree of substitution. The synthesized cationic cellulose was characterized through FTIR, XRD, NMR, FESEM and TGA. The activity of cationized cellulose as wet-end additive was tested for bagasse, wheat straw and recycled pulps due to their shorten fiber and feeble pulp characters than wood pulp.Hydrogels are widely used for wound healing applications due to their similarity to the native extracellular matrix (ECM) and ability to provide a moist environment. However, lac