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42; 95% CI 1.73-3.37). In addition, we demonstrated developing contralateral UTUC was not associated with poor prognosis by using Kaplan-Meier and multivariable analysis. Our findings suggest that metachronous contralateral UTUC is comparatively rare, and has not impact on survival. Importantly, patients with younger age, small tumours, and the presence of bladder cancer were more likely to develop a contralateral tumor, which may provide a rationale for lifelong surveillance in high-risk patients.Stargardt disease, the most common inhe