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Medications and Therapy For ADHD A combination of medication and therapy can help manage ADHD symptoms. The medication treats the brain while therapy helps people manage and develop skills. Stimulants such as methylphenidate or Lisdexamfetamine can increase levels of two chemicals that transmit messages between cells within the brain. This improves attention and impulse control. Stimulants may cause negative side effects, like insomnia, a decreased appetite and a rise in blood pressure and