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There is substantial evidence that IGF-1 and GLP-1 analogues penetrate the blood-brain barrier (BB and exhibit neuroprotective functions, including synaptic formation, neuronal plasticity, protein synthesis, and autophagy. Conclusively, this review represents the therapeutic potential of IGF-1 and GLP-1 signaling target activators in ameliorating neurological disorders.The α7 subtype of the nicotinic acetylcholine receptor (α7 nAChR coded by Chrna7) is known to regulate the cholinergic ascending anti-inflammatory pathway. We previousl