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How Does ADHD Medication Work? ADHD is treated with stimulants. They regulate the levels of neurotransmitters (two brain chemicals) that transmit messages between neurons to improve attention and reduce excessive hyperactivity. 20 % of people are not responsive to stimulants like amphetamine or methylphenidate. This may be due to the chemistry of their bodies or other medications they are taking. What are the signs of ADHD? If you suspect your child may have ADHD and you suspect it, first visit