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How Does Medication For ADHD Work? Stimulants boost the levels of norepinephrine and dopamine in your brain, assisting in improving concentration and impulse control. They are available in immediate release (short-acting) and extended-release tablets taken once a day, usually in the morning. Nonstimulant medications can improve concentration and impulse control however they take longer to work. Atomoxetine (Strattera) and Guanfacine (Viloxazine) are in the antidepressan