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In this chapter we outline three distinct quantitative approaches suitable for targeting apolipoproteins (1) multiplex immunoassays, (2) mass spectrometric immunoassay, and (3) multiple reaction monitoring, mass spectrometric quantification. We also discuss management of pre-analytical and experimental design variables.Sarcopenia, the age-dependent decline of muscle mass and performance, is a common condition among elderly population and is related to numerous adverse health outcomes. Due to the effect of sarcopenia on quality of life, d