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6 and ALI ≥32.6 groups), and the median OS times were 19.23 and 39.97 months, respectively (p less then 0.01). A multivariable Cox regression model confirmed that ALI and chemotherapy were independent prognostic factors for OS in patients with NSCLC. OS in the high ALI group was better than that in the low ALI group (HR 1.39; 95% CI 1.03-1.89; p = 0.03). Conclusions Patients with a low ALI tend to have lower OS among those with metastatic NSCLC, and the ALI can serve as an effective prognostic factor for NSCLC patients.The interior of the