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, GABA and melatonin) and wake maintenance (e.g., serotonin, acetylcholine and glutamate). Specifically, this review examines how altered sleep structure could be related to neurobiological alterations or genetic mutations and the implications this may have for potential pharmacological treatments in individuals with ASD. To assess the performance of the Antibody Prevalence in Chinese Patients with Epilepsy and Encephalopathy (APE -CHN) and Response to Immunotherapy in Chinese Patients with Epilepsy and Encephalopathy (RITE -CHN) scores